FAM185A
Description
The FAM185A (family with sequence similarity 185 member A) is a protein-coding gene located on chromosome 7.
The FAM185A (Gene Family with sequence similarity 185, member A) is a protein that in humans is encoded by the FAM185A gene. The FAM185A gene is found on the positive strand of Chromosome 7 at 7q22.1. The gene begins 102,389,399bp from the p-terminus of the chromosome and ends at 102,449,672bp from the p-terminus; it covers a total of 73,308 basepairs. The protein encoded by this gene is characterized by the presence of multiple copies of DUF4098 (Domain of unknown function, 4098) near its C-terminus. It is described as a Long Interspersed Nuclear Element (LINE), a subclass of penaeid repetitive elements (PREs).
== Homology == Homologs have been found in many animal species, but no fungal, plant, or other more distantly related homologs have been found. Clades that are known to have FAM185A orthologs include:
Chordata Echinodermata Hemichordata Arthropoda Mollusca Annelida Cnidaria Heterokontophyta Choanoflagellatea Clades in which no orthologs or homologs have been found include:
Fungi Plantae Nematoda Platyhelminthes Rotifera Tardigrada Nemertea Bryozoa
== Protein ==
=== Isoforms === Two protein forming isoforms are known to be transcribed from the FAM185A gene. Isoform 1 is the longer isoform, resulting in a protein 392 amino acids long. Isoform 2 is a shortened version of Isoform 1 resulting from alternative splicing of the mRNA. Isoform 2 forms a 275aa protein; it is missing a 118aa segment near the N-terminus of the protein.
=== DUF4098 === Domain of Unknown Function 4098 is domain found in all FAM185A orthologs, as well as in some other non-orthologous species.
FAM185A is also known as -.
