FAM178B
Description
The FAM178B (family with sequence similarity 178 member B) is a protein-coding gene located on chromosome 2.
FAM178B is a protein coding gene located on chromosome 2, specifically at locus 2q11.2. It is also known as Family with Sequence Similarity 178, Member B, and HSPC234. The gene spans 110,720 base pairs and contains 827 amino acids. It has two isoforms of the gene transcript that exist by alternative splicing, and one gene precursor. SLF2 (FAM178A) is an important paralog of FAM178B. The protein has a molecular weight of 76.5 kilodaltons and an isoelectric point of 5.47. It has been phenotypically associated with bipolar disease due to its locus, as well as body mass index (BMI), and cell adhesion. A proposed structure for the protein can be found in the images for proposed structures.
FAM178B is a protein-coding gene that plays a role in the DNA damage response (DDR) pathway by regulating post-replication repair of UV-damaged DNA, and genomic stability maintenance. The gene has 6 transcript splice variants, and its protein has been phenotypically associated with bipolar disease, body mass index (BMI), and cell adhesion.
FAM178B is also known as -.
