FAM163A
Description
The FAM163A (family with sequence similarity 163 member A) is a protein-coding gene located on chromosome 1.
FAM163A is a protein encoded by the FAM163A gene. It has been implicated in promoting proliferation and anchorage-independent growth of neuroblastoma cancer cells. This protein has also been found to be up-regulated in the lung tissue of chronic smokers. FAM163A is found on human chromosome 1q25.2 and its protein product is 167 amino acids long. FAM163A contains a highly conserved signal peptide sequence, coded for by the first ~37 amino acids in its sequence.
Gene
FAM163A is approximately 2,927 base pairs long, containing five exons. The coding region of the gene is very short (~500 base pairs), with a long 3' untranslated region (UTR). FAM163A is located on the positive strand of chromosome 1, near three other genes: TOR1AIP1, TOR1AIP2, and TDRD5.
mRNA
Elevated levels of NDSP were found in 43 out of 45 neuroblastoma tumor samples and in five bone marrow samples. NDSP is associated with increased risk for development of cancer metastasis in bone marrow as well as neural tissue.
FAM163A, also known as cebelin and neuroblastoma-derived secretory protein (NDSP), is a protein that promotes proliferation and anchorage-independent growth of neuroblastoma cancer cells. It is upregulated in the lung tissue of chronic smokers. FAM163A is found on human chromosome 1q25.2 and its protein product is 167 amino acids long. The protein contains a conserved signal peptide sequence in the first 37 amino acids.
FAM163A is also known as C1orf76, NDSP.
Associated Diseases
- diabetes mellitus, permanent neonatal 4
- permanent neonatal diabetes mellitus 1
- hemoglobin E-beta-thalassemia syndrome
- hemoglobin D disease
- diabetes mellitus, transient neonatal, 3
- congenital dyserythropoietic anemia type 4
- dehydrated hereditary stomatocytosis
- immunodeficiency 69
- hemolytic anemia due to diphosphoglycerate mutase deficiency
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction
- cancer
