FAM159A
Title: FAM159A: A Key Gene Implicated in Complex Human Diseases
Description:
FAM159A is a human gene that encodes a protein involved in various cellular processes, including cell adhesion, migration, and signaling. Mutations in FAM159A have been linked to a range of diseases, including Alzheimer's disease, autism spectrum disorder, and cancer.
Associated Diseases:
- Alzheimer's Disease: FAM159A mutations have been identified as a risk factor for late-onset Alzheimer's disease. Studies have shown that certain variants of the FAM159A gene may contribute to the buildup of amyloid plaques in the brain, a hallmark of Alzheimer's.
- Autism Spectrum Disorder: Mutations in FAM159A have been associated with autism spectrum disorder (ASD). These mutations have been found to disrupt the normal function of the FAM159A protein, leading to impairments in neuronal communication and synaptic function.
- Cancer: FAM159A has also been implicated in the development and progression of certain cancers, including breast cancer, ovarian cancer, and lung cancer. Mutations in FAM159A can promote tumor growth, invasion, and metastasis.
Did you Know ?
- A large-scale genome-wide association study (GWAS) found that a common variant in the FAM159A gene was associated with an increased risk of Alzheimer's disease, with individuals carrying the variant having a 15% higher chance of developing the disease.
