FAM135B
Description
The FAM135B (family with sequence similarity 135 member B) is a protein-coding gene located on chromosome 8.
FAM135B is a human gene that codes for a protein of unknown function. It is well conserved in primates, rodents, zebra fish. It has one paralog, FAM135A.
== Gene == FAM135B is located on the long arm of Chromosome 8 in humans on the anti-sense located at 24.23. The following genes are near FAM135B on the chromosome:
COL22A1: Collagen producing gene that is a cell adhesion ligand for skin epithelial cells and fibroblast FLJ45972: Gene function is unknown KCNK9: Gene that encodes for a two pore potassium channel
== Expression == FAM135B is expressed in the brain, ear, eye, pancreas and testis. Within the brain, expression is apparent within the motor nucleus of trigeminal In addition, it is mainly expressed in normal health states, although it has shown moderate expression in glioma, non-neoplasima as well as expression in germ cell tumors.
== Interactions == FAM135B has shown to interact with KAT5, a gene that encodes for a histone acetyltransferase through yeast two-hybrid experimentation.
== Protein == The protein encoded on FAM135 is 1406 amino acids long. The protein contains a region called DUF676, believed to be a putative serine esterase as well as two protein regions called DUF3657.
== Clinical significance == FAM135B has shown to be expressed in individuals with extrapulmonary tuberculosis.
FAM135B is a gene of unknown function that is well conserved across various species, including primates, rodents, and zebrafish. It is located on chromosome 8 and has been found to be expressed in several tissues, including the brain, ear, eye, pancreas, and testis. Its expression has also been observed in certain types of tumors, such as gliomas and germ cell tumors. Studies have shown that FAM135B interacts with the KAT5 gene, which encodes for a histone acetyltransferase. This gene has been observed to be expressed in individuals with extrapulmonary tuberculosis.
FAM135B is also known as C8ORFK32.
