FAM107B
Description
The FAM107B (family with sequence similarity 107 member B) is a protein-coding gene located on chromosome 10.
FAM107B is a human gene situated on the short arm of chromosome 10, specifically at position p13. It's also known by other names, including C10orf45, FLJ45505, MGC11034, and MGC90261. The gene contains a conserved domain, DUF1151, which belongs to a family of eukaryotic proteins with unknown functions. FAM107B is expressed in numerous tissues throughout the human body without showing a significant preference for any specific tissue. It is present in all stages of human development. The FAM107B mRNA is 3785 base pairs long and consists of five exons. The protein encoded by FAM107B is known as LOC83641 and is 306 amino acids long. Based on AceView data, there are 27 spliced variants, 2 unspliced variants, and 27 mRNAs associated with FAM107B. Among these, only 23 spliced and unspliced mRNAs are confirmed to produce functional proteins.
The function of FAM107B is currently unknown. It contains a conserved domain, DUF1151, which is found in various eukaryotic proteins with undetermined functions. The gene is widely expressed across human tissues without any specific tissue preference, and its presence is observed throughout human development.
FAM107B is also known as C10orf45, HITS.
Associated Diseases
- hearing loss, autosomal recessive
- deafness, aminoglycoside-induced
- autosomal dominant nonsyndromic hearing loss 17
- autosomal dominant nonsyndromic hearing loss 7
- autosomal recessive nonsyndromic hearing loss 1B
- autosomal dominant nonsyndromic hearing loss
- autosomal dominant nonsyndromic hearing loss 40
- hearing loss, autosomal dominant 74
- hearing loss, autosomal recessive 117
- hearing loss, autosomal recessive 110
