FAM105A
FAM105A: Exploring the Gene Linked to Obesity and Metabolic Disorders
Description
FAM105A (family with sequence similarity 105, member A) is a gene located on chromosome 11p15.5. It encodes a protein known as family with sequence similarity 105 member A, which is involved in various cellular processes, including protein synthesis, cell growth, and metabolism.
Associated Diseases
Variants in the FAM105A gene have been linked to several obesity-related disorders, including:
- Obesity: FAM105A mutations have been found in individuals with severe obesity, particularly those with early-onset or extreme obesity.
- Metabolic syndrome: FAM105A variants have also been associated with an increased risk of developing metabolic syndrome, a cluster of conditions that includes obesity, high blood pressure, high cholesterol, and impaired glucose metabolism.
- Type 2 diabetes: Mutations in FAM105A have been linked to an increased susceptibility to type 2 diabetes, a chronic condition characterized by high blood sugar levels.
Did you Know ?
A large-scale genetic study involving over 400,000 individuals revealed that a common variant in the FAM105A gene is associated with a 1.3-fold increased risk of obesity.
