EXOSC7
Description
The EXOSC7 (exosome component 7) is a protein-coding gene located on chromosome 3.
Exosome component 7, also known as EXOSC7, is a human gene, the protein product of which is part of the exosome complex. Exosome component 7 has been shown to interact with: Exosome component 1, Exosome component 2, and Exosome component 6.
EXOSC7, also known as RRP42, is a non-catalytic component of the RNA exosome complex. This complex plays a crucial role in various cellular RNA processing and degradation events. Within the nucleus, it contributes to the proper maturation of stable RNA species like rRNA, snRNA, and snoRNA, as well as the elimination of RNA processing by-products and non-coding transcripts such as antisense RNA species and promoter-upstream transcripts (PROMPTs). It also handles mRNAs with processing defects, limiting their export to the cytoplasm. The RNA exosome may also be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex participates in general mRNA turnover and specifically degrades unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions. It also plays a role in RNA surveillance pathways, preventing the translation of aberrant mRNAs. Additionally, it seems to be involved in the degradation of histone mRNA. The catalytically inactive RNA exosome core complex of 9 subunits (Exo-9) is thought to be key in binding and presenting RNA for ribonucleolysis, and serves as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
EXOSC7 is also known as EAP1, RRP42, Rrp42p, hRrp42p, p8.
