EVI5L
Description
The EVI5L (ecotropic viral integration site 5 like) is a protein-coding gene located on chromosome 19.
EVI5L (Ecotropic Viral Integration Site 5-Like) is a protein encoded by the EVI5L gene in humans. It belongs to the Ras superfamily of monomeric guanine nucleotide-binding (G) proteins and functions as a GTPase-activating protein (GAP) with a broad specificity. Studies have shown that EVI5L exhibits significant Rab2A- and Rab10-GAP activity. The EVI5L gene spans 34,701 base pairs and produces an unprocessed mRNA of 3,756 nucleotides. It consists of 19 exons that code for an 805 amino acid protein. EVI5L is located on chromosome 19, specifically on the short arm (p) in region 1, band 3, and sub-band 2 (19p13.2), starting at base pair 7,830,275 and ending at 7,864,976. It is encoded on the plus strand and is situated near the CLEC4M gene, which is involved in peptide antigen transport. EVI5L contains a RAB-GAP TBC domain, which regulates membrane trafficking by cycling between inactive (GDP-bound) and active (GTP-bound) conformations. Additionally, it has the apolipophorin-III and tetratricopeptide repeat (TPR) domains.
EVI5L is also known as -.
