ETV3
ETV3: A Gene with a Role in Leukemia and Breast Cancer
Description
ETV3 (also known as Ets Variant 3), is a gene that plays a crucial role in cell growth, differentiation, and development. It belongs to the Ets family of transcription factors, which regulate gene expression by binding to specific DNA sequences.
Associated Diseases
Mutations or alterations in the ETV3 gene have been linked to several types of cancer, including:
- Acute Myeloid Leukemia (AML): ETV3 mutations are found in approximately 15-20% of AML cases. These mutations can result in the overexpression of ETV3, leading to abnormal cell growth and uncontrolled proliferation.
- Breast Cancer: ETV3 overexpression has been observed in a subset of breast cancers, particularly in estrogen receptor (ER)-positive tumors. It is associated with increased proliferation, reduced apoptosis, and impaired immune response.
Did you Know ?
- Studies have shown that ETV3 mutations are more common in younger AML patients, with a higher prevalence in infants and children.
