ESCO1
Description
The ESCO1 (establishment of sister chromatid cohesion N-acetyltransferase 1) is a protein-coding gene located on chromosome 18.
ESCO1, encoded by the ESCO1 gene in humans, is a protein belonging to a conserved family of acetyltransferases involved in sister chromatid cohesion. This means it helps ensure that duplicated chromosomes (sister chromatids) are properly connected and separated during cell division.
ESCO1 is an acetyltransferase that plays a crucial role in establishing sister chromatid cohesion during DNA replication. It ensures that only sister chromatids pair together by coupling cohesion and replication processes. Unlike the structural cohesins, ESCO1 is only required during the S phase. It acts by acetylating SMC3, a component of the cohesin complex.
ESCO1 is also known as A930014I12Rik, CTF, ECO1, EFO1, ESO1.
Associated Diseases
- endometrial cancer
- urinary bladder cancer
- cholesterol-ester transfer protein deficiency
- hypertriglyceridemia 2
- urinary bladder carcinoma
- cancer
- endometrium neoplasm
