ERO1LB
ERO1-Like Protein: Essential for Protein Folding, ER Stress, and Disease
Description:
ERO1-like protein (ERO1L), also known as ER oxidoreductase 1-like protein, is a membrane-bound protein located in the endoplasmic reticulum (ER). It is an enzyme that catalyzes the oxidation of protein disulfide bonds, which is crucial for the correct folding and maturation of secretory and membrane proteins.
Associated Diseases:
- Neurodegenerative diseases: Mutations in ERO1L have been linked to Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). These diseases are characterized by protein misfolding and aggregation, which may be exacerbated by impaired ERO1L function.
- Cardiovascular diseases: ERO1L dysfunction has been implicated in the development of heart failure and arrhythmias. Animal studies have shown that loss of ERO1L in the heart leads to reduced contractility and increased susceptibility to oxidative stress.
- Metabolic diseases: ERO1L is involved in insulin signaling and glucose metabolism. Disrupted ERO1L activity has been associated with insulin resistance and type 2 diabetes.
- Inflammatory diseases: ERO1L plays a role in regulating inflammatory responses. Increased ERO1L activity has been observed in chronic inflammatory conditions such as rheumatoid arthritis and inflammatory bowel disease.
Did you Know ?
ERO1L is responsible for oxidizing over 50% of protein disulfide bonds in the ER. This underscores its critical role in protein folding and ER homeostasis.
