ERI1
Description
The ERI1 (exoribonuclease 1) is a protein-coding gene located on chromosome 8.
ERI1 is a 3'-5' exoribonuclease that primarily degrades histone mRNAs. It binds to the 3'-end of histone mRNAs, recognizing the 5'-ACCCA-3' sequence within their stem-loop structure. ERI1's activity is crucial for the degradation of histone mRNAs after DNA replication, playing a key role in regulating histone mRNA levels. ERI1 can also degrade the 3'-overhangs of siRNAs in vitro, suggesting a possible role in RNA interference (RNAi). Additionally, ERI1 is required for 5.8S rRNA 3'-end processing and binds to 5.8S ribosomal RNA. ERI1 demonstrates biphasic kinetics during RNA degradation, with rapid hydrolysis of the final three unpaired RNA nucleotides followed by slower cleavage through the stem. Notably, ERI1's role in RNA metabolism is critical for chondrogenesis.
ERI1 is also known as 3'HEXO, HEXO, HXAL, SEMDGC, SEMDGS, THEX1.
