ENY2
Description
The ENY2 (ENY2 transcription and export complex 2 subunit) is a protein-coding gene located on chromosome 8.
ENY2 is a human gene that encodes a protein involved in mRNA export and transcription activation.
ENY2 plays a crucial role in the export of messenger RNA (mRNA) from the nucleus to the cytoplasm, a process essential for protein synthesis. This function is achieved through its association with two protein complexes: TREX-2 and SAGA. TREX-2 facilitates mRNA export through nuclear pores, while SAGA, a multi-protein complex involved in gene regulation, activates transcription by modifying chromatin structure. Within SAGA, ENY2 participates in a subcomplex responsible for removing ubiquitin tags from histones H2A and H2B, thus influencing gene expression. ENY2's involvement in both TREX-2 and SAGA complexes highlights its central role in coordinating transcription and mRNA export, contributing to the efficient and accurate production of proteins.
ENY2 is also known as DC6, Sus1, e(y)2.
