ENGASE
Description
The ENGASE (endo-beta-N-acetylglucosaminidase) is a protein-coding gene located on chromosome 17.
The ENGASE gene encodes a cytosolic enzyme responsible for breaking down peptides and proteins with mannose modifications. This process releases free oligosaccharides. The enzyme is essential for the breakdown and processing of glycoproteins within the cell.
ENGase is an endoglycosidase that removes N-glycans from glycoproteins by breaking the beta-1,4-glycosidic bond within the N,N'-diacetylchitobiose core. This enzyme plays a role in processing free oligosaccharides in the cytosol.
ENGASE is also known as -.
Associated Diseases
- endophthalmitis
- fucosidosis
- nonpapillary renal cell carcinoma
- acute kidney failure
- lysosomal storage disease
