ENC1
Description
The ENC1 (ectodermal-neural cortex 1) is a protein-coding gene located on chromosome 5.
Ectoderm-neural cortex protein 1 is a protein that in humans is encoded by the ENC1 gene. DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions.
ENC1 is also known as CCL28, ENC-1, KLHL35, KLHL37, NRPB, PIG10, TP53I10.
Associated Diseases
- breast cancer
- cancer
- cholesterol-ester transfer protein deficiency
- hyperlipoproteinemia type V
- hypertriglyceridemia 2
- hyperinsulinism due to INSR deficiency
- pentosuria
- Crigler-Najjar syndrome type 2
- glycogen storage disease III
- glycogen storage disease VI