EMCN
Description
The EMCN (endomucin) is a protein-coding gene located on chromosome 4.
Endomucin is a protein encoded by the EMCN gene in humans. It serves as a marker for endothelial cells and hematopoietic stem cells. Endomucin is a mucin-like sialoglycoprotein that disrupts the assembly of focal adhesion complexes and prevents cells from interacting with the extracellular matrix.
Endothelial sialomucin, also known as endomucin or mucin-like sialoglycoprotein, plays a crucial role in regulating cell adhesion by interfering with the assembly of focal adhesion complexes. This protein inhibits the interaction between cells and the extracellular matrix, influencing cell migration and signaling.
EMCN is also known as EMCN2, MUC14.
Associated Diseases
- nonpapillary renal cell carcinoma
- hemoglobin E-beta-thalassemia syndrome
- beta-thalassemia-X-linked thrombocytopenia syndrome
- dehydrated hereditary stomatocytosis
- hemoglobin D disease
- gluthathione peroxidase deficiency
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction
- primary familial polycythemia due to EPO receptor mutation
