EMC9
Description
The EMC9 (ER membrane protein complex subunit 9) is a protein-coding gene located on chromosome 14.
EMC9, also known as FAM158A, is a component of the endoplasmic reticulum (ER) membrane protein complex (EMC). The EMC enables the energy-independent insertion of newly synthesized membrane proteins into the ER membrane. EMC9 preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features, such as charged and aromatic residues. It is involved in the cotranslational insertion of multi-pass membrane proteins and the post-translational insertion of tail-anchored (TA) proteins. By mediating the proper cotranslational insertion of N-terminal transmembrane domains, EMC9 controls the topology of multi-pass membrane proteins, such as G protein-coupled receptors. It plays a role in various cellular processes by regulating the insertion of proteins into membranes.
EMC9 is also known as C14orf122, CGI-112, FAM158A.
