EMC8
Description
The EMC8 (ER membrane protein complex subunit 8) is a protein-coding gene located on chromosome 16.
EMC8 is a component of the endoplasmic reticulum membrane protein complex (EMC) that facilitates the energy-independent insertion of newly synthesized membrane proteins into the endoplasmic reticulum. It preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features like charged and aromatic residues. EMC8 plays a role in the cotranslational insertion of multi-pass membrane proteins, where stop-transfer membrane-anchor sequences become ER membrane-spanning helices. It is also essential for the post-translational insertion of tail-anchored/TA proteins into the endoplasmic reticulum membranes. By ensuring the correct cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with the translocated N-terminus residing in the ER lumen, EMC8 controls the topology of multi-pass membrane proteins, including G protein-coupled receptors. Through its regulation of protein insertion into membranes, EMC8 indirectly influences numerous cellular processes.
EMC8 is also known as C16orf2, C16orf4, COX4NB, FAM158B, NOC4.
Associated Diseases
- diverticulitis
- colorectal cancer
- systemic lupus erythematosus
- retinitis pigmentosa and erythrocytic microcytosis
