ELMO3
Description
The ELMO3 (engulfment and cell motility 3) is a protein-coding gene located on chromosome 16.
ELMO3, also known as Engulfment and cell motility 3, is a human gene. The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 (DOCK1) protein to promote phagocytosis and effect cell shape changes.
ELMO3 is involved in cytoskeletal rearrangements essential for the engulfment of apoptotic cells and cell motility. It works in conjunction with DOCK1 and CRK proteins. Initially, ELMO3 was thought to be necessary, in complex with DOCK1, for activating Rac Rho small GTPases. ELMO3 might enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
ELMO3 is also known as CED-12, CED12, ELMO-3.
