ELL
Description
The ELL (elongation factor for RNA polymerase II) is a protein-coding gene located on chromosome 19.
ELL is a human gene that encodes an elongation factor involved in RNA polymerase II transcription.
ELL is a component of the super elongation complex (SEC), which increases the rate of RNA polymerase II transcription by reducing pausing at various DNA locations. ELL also participates in the little elongation complex (LEC), regulating the transcription of small nuclear RNA (snRNA) genes by RNA polymerases II and III. It specifically facilitates the elongation phase of snRNA gene transcription driven by RNA polymerases II and III. Before joining the SEC, ELL plays an early role in stabilizing RNA polymerase II recruitment, initiation, and entry into the pause site. It contributes to stabilizing the pre-initiation complex and early elongation. These functions are supported by various studies.
ELL is also known as C19orf17, ELL1, MEN, PPP1R68.
Associated Diseases
- carcinoma of liver and intrahepatic biliary tract
- central nervous system primitive neuroectodermal neoplasm
- skin squamous cell carcinoma
