ELK4
Description
The ELK4 (ETS transcription factor ELK4) is a protein-coding gene located on chromosome 1.
ELK4 is a protein encoded by the ELK4 gene in humans. It belongs to the Ets family of transcription factors and the ternary complex factor (TCF) subfamily. TCF proteins form a complex with the serum response factor (SRF) and the serum response element in the promoter of the c-fos proto-oncogene. ELK4 is phosphorylated by the kinases MAPK1 and MAPK8. It has been shown to interact with BRCA1 and SRF. Several transcript variants have been described for this gene.
ELK4 plays a role in both activating and suppressing gene expression. It interacts with the SIRT7 protein, leading to SIRT7's recruitment and stabilization at gene promoters. This interaction results in the removal of an acetyl group from histone H3 at position Lys-18 (H3K18Ac), which ultimately represses gene transcription. ELK4 forms a complex with the serum response factor (SRF) and requires SRF to be bound to DNA for this complex to form. ELK4 interacts extensively with the DNA region upstream of the SRF binding site but does not bind to DNA on its own.
ELK4 is also known as SAP1.
Associated Diseases
- carcinoma of liver and intrahepatic biliary tract
- skin basal cell carcinoma
- urinary bladder carcinoma
- pancreatic ductal adenocarcinoma
