EIF5
Description
The EIF5 (eukaryotic translation initiation factor 5) is a protein-coding gene located on chromosome 14.
Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene. EIF5 is a GTPase-activating protein.
EIF5 is a component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans the mRNA 5'-untranslated region, and locates the initiation codon. It acts as a GTPase-activating protein, promoting GTP hydrolysis by eIF2G. EIF5 interacts with both EIF1 and EIF1A during scanning, and this interaction with EIF1A helps maintain EIF1 within the open 43S PIC. Upon start codon recognition, EIF5 induces eIF2G to hydrolyze GTP, causing a conformational change in the PIC to a closed state. This change increases the affinity of EIF5 for EIF2-beta, leading to the release of EIF1 from the PIC. Finally, EIF5 stabilizes the PIC in its closed conformation.
EIF5 is also known as EIF-5, EIF-5A.
