EIF4E2
Description
The EIF4E2 (eukaryotic translation initiation factor 4E family member 2) is a protein-coding gene located on chromosome 2.
Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene. It belongs to the eukaryotic translation initiation factor 4E family.
== Interactions == EIF4E2 has been shown to interact with ARIH1.
EIF4E2 recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. It acts as a repressor of translation initiation, unlike EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3) suggesting it acts by competing with EIF4E and blocking assembly of eIF4F at the cap. In P-bodies, it is a component of a complex that promotes miRNA-mediated translational repression. EIF4E2 is involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism. {ECO:0000250|UniProtKB:Q8BMB3, ECO:0000269|PubMed:17368478, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:25624349, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:33581076, ECO:0000269|PubMed:9582349}
EIF4E2 is also known as 4E-LP, 4EHP, EIF4EL3, IF4e, h4EHP.
