EIF3M
Description
The EIF3M (eukaryotic translation initiation factor 3 subunit M) is a protein-coding gene located on chromosome 11.
Eukaryotic translation initiation factor 3, subunit M (eIF3m), also known as PCI domain containing 1 (herpesvirus entry mediator) (PCID1), is a protein that in humans is encoded by the EIF3M gene. HFLB5 encodes a broadly expressed protein containing putative membrane fusion domains that acts as a receptor or coreceptor for entry of herpes simplex virus (HSV).
The EIF3M protein is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is crucial for multiple steps in protein synthesis initiation. It associates with the 40S ribosome and facilitates the recruitment of other initiation factors (eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi, and eIF-5) to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex plays a role in mRNA recruitment to the 43S PIC and the scanning process for AUG recognition. It is also involved in the disassembly and recycling of post-termination ribosomal complexes, preventing premature joining of the 40S and 60S ribosomal subunits before initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation, and apoptosis, using different modes of RNA stem-loop binding for translational activation or repression.
EIF3M is also known as B5, GA17, PCID1, TANGO7, hfl-B5.
