EIF3L
Description
The EIF3L (eukaryotic translation initiation factor 3 subunit L) is a protein-coding gene located on chromosome 22.
EIF3L is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which plays a crucial role in the initiation of protein synthesis. The eIF-3 complex binds to the 40S ribosome and assists in recruiting other initiation factors, such as eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi, and eIF-5, to form the 43S pre-initiation complex (43S PIC). This complex helps in the recruitment of mRNA to the 43S PIC and the scanning of the mRNA for the AUG start codon. Additionally, eIF-3 is involved in the disassembly and recycling of ribosomes after translation is completed, preventing premature joining of the ribosomal subunits before initiation. It is specifically involved in the initiation of translation for mRNAs related to cell proliferation, including cell cycle control, differentiation, and apoptosis, utilizing different RNA stem-loop binding mechanisms for either translational activation or repression.
EIF3L is also known as EIF3EIP, EIF3S11, EIF3S6IP, HSPC021, HSPC025, MSTP005.
