EIF3K
Description
The EIF3K (eukaryotic translation initiation factor 3 subunit K) is a protein-coding gene located on chromosome 19.
EIF3K is a human gene that encodes the eukaryotic translation initiation factor 3 subunit K (eIF3k), a protein involved in protein synthesis. eIF3k is a component of the eIF3 complex, a large multi-subunit protein complex essential for translation initiation. The eIF3 complex binds to the 40S ribosomal subunit and promotes the formation of the 43S preinitiation complex, a crucial step in the translation process. eIF3k has been shown to interact with Cyclin D3 and eIF3a.
EIF3K, also known as eIF3k, is a subunit of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is essential for various steps in protein synthesis initiation. The eIF-3 complex binds to the 40S ribosomal subunit and facilitates the assembly of the 43S preinitiation complex by recruiting other initiation factors like eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi, and eIF-5. This complex then promotes mRNA recruitment to the 43S preinitiation complex and scans the mRNA for the AUG start codon. Additionally, the eIF-3 complex plays a role in disassembling and recycling post-termination ribosomal complexes, preventing premature joining of the 40S and 60S ribosomal subunits before initiation. It also selectively targets and initiates translation of specific mRNAs involved in cell proliferation, including those regulating cell cycle, differentiation, and apoptosis. The eIF-3 complex utilizes different modes of RNA stem-loop binding to either activate or repress translation.
EIF3K is also known as ARG134, EIF3-p28, EIF3S12, HSPC029, M9, MSTP001, PLAC-24, PLAC24, PRO1474, PTD001.
Associated Diseases
- Brugada syndrome
- familial atrial fibrillation
- amelogenesis imperfecta
- dentin dysplasia type I
- dentinogenesis imperfecta type 3
- dentin dysplasia type II
- familial sick sinus syndrome
- long QT syndrome 9
- arrhythmogenic right ventricular dysplasia 10
- sick sinus syndrome 1
- sinoatrial node dysfunction and deafness
- long QT syndrome 5
- cardiomyopathy, dilated, 2F
