EIF3J-AS1
Description of Eif3j-as1
Eif3j-as1 (eukaryotic translation initiation factor 3 subunit j antisense RNA 1) is a long non-coding RNA (lncRNA) that plays crucial roles in gene regulation and cellular processes. It is located on chromosome 11 in humans and is approximately 1,400 nucleotides long.
Eif3j-as1 has been found to interact with various proteins and RNA molecules, forming complexes that influence gene expression. It can regulate the expression of genes involved in cell proliferation, differentiation, apoptosis, and immune response.
Associated Diseases
Dysregulation of eif3j-as1 has been linked to several diseases, including:
- Cancer: Eif3j-as1 overexpression has been observed in various cancers, including breast, lung, and liver cancer. It promotes cancer cell proliferation, migration, and invasion, contributing to tumorigenesis and disease progression.
- Neurodegenerative diseases: Downregulation of eif3j-as1 has been implicated in neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease. It has been found to regulate neuronal cell growth, survival, and synaptic plasticity.
- Cardiovascular diseases: Dysregulation of eif3j-as1 has also been linked to cardiovascular diseases, including atherosclerosis and heart failure. It affects the expression of genes involved in vascular remodeling and inflammation, contributing to disease pathogenesis.
Did you Know ?
- In a study of breast cancer patients, those with high levels of eif3j-as1 had a significantly worse prognosis than those with low levels. The researchers found that eif3j-as1 promoted cancer cell proliferation and metastasis, suggesting its potential as a therapeutic target.
