EIF3J
Description
The EIF3J (eukaryotic translation initiation factor 3 subunit J) is a protein-coding gene located on chromosome 15.
Eukaryotic translation initiation factor 3 subunit J (eIF3j) is a protein that in humans is encoded by the EIF3J gene.
== Interactions == eIF3j has been shown to interact with eIF3a.
EIF3J plays a critical role in protein synthesis by being a subunit of the eukaryotic translation initiation factor 3 (eIF-3) complex. This complex is essential for various steps in protein synthesis initiation, including the association with the 40S ribosome, recruitment of key initiation factors (eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi, and eIF-5) to form the 43S pre-initiation complex (43S PIC), and facilitating mRNA recruitment to the 43S PIC for scanning and AUG recognition. Additionally, eIF-3 is involved in the disassembly and recycling of post-termination ribosomal complexes, preventing premature joining of ribosomal subunits before initiation. Furthermore, eIF-3 selectively targets and initiates the translation of mRNAs involved in cell proliferation, including those related to cell cycle, differentiation, and apoptosis, through distinct RNA stem-loop binding mechanisms that can either activate or repress translation.
EIF3J is also known as EIF3S1, eIF3-alpha, eIF3-p35.
Associated Diseases
- hereditary sensory and autonomic neuropathy with spastic paraplegia
- hereditary spastic paraplegia 11
- hereditary spastic paraplegia
- cancer
- Alzheimer disease
