EIF3I
Description
The EIF3I (eukaryotic translation initiation factor 3 subunit I) is a protein-coding gene located on chromosome 1.
Eukaryotic translation initiation factor 3 subunit I (eIF3i) is a protein that in humans is encoded by the EIF3I gene.
== Interactions == eIF3i has been shown to interact with TGF beta 1 and eIF3a.
The EIF3I gene encodes a subunit of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is crucial for several steps in the initiation of protein synthesis. This complex interacts with the 40S ribosome and facilitates the recruitment of other initiation factors, forming the 43S pre-initiation complex (43S PIC). It also assists in mRNA recruitment to the 43S PIC, scanning for the start codon (AUG), and the disassembly and recycling of ribosomal complexes. Importantly, the eIF-3 complex plays a role in regulating the translation of specific mRNAs involved in cell proliferation, including cell cycle control, differentiation, and apoptosis, and it can either activate or repress translation depending on the RNA sequence.
EIF3I is also known as EIF3S2, PRO2242, TRIP-1, TRIP1, eIF3-beta, eIF3-p36.
