EIF3G
Description
The EIF3G (eukaryotic translation initiation factor 3 subunit G) is a protein-coding gene located on chromosome 19.
EIF3G is a human gene that encodes the Eukaryotic translation initiation factor 3 subunit G (eIF3g) protein.
EIF3G is a subunit of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is essential for various steps in protein synthesis initiation. The eIF-3 complex binds to the 40S ribosome, facilitating the recruitment of other initiation factors (eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi, and eIF-5) to form the 43S pre-initiation complex (43S PIC). This complex then promotes the recruitment of mRNA and its scanning for the start codon (AUG). Additionally, eIF-3 is involved in the disassembly and recycling of post-termination ribosomal complexes, preventing premature joining of the ribosomal subunits. Notably, eIF-3 selectively initiates translation of specific mRNAs involved in cell growth processes, such as cell cycle regulation, differentiation, and apoptosis. EIF3G can bind to 18S rRNA, a component of the small ribosomal subunit.
EIF3G is also known as EIF3-P42, EIF3S4, eIF3-delta, eIF3-p44.
Associated Diseases
- narcolepsy-cataplexy syndrome
- cancer
- Alzheimer disease
- narcolepsy
- urinary bladder carcinoma
- blood platelet disease
