EIF1AY
Description
The EIF1AY (eukaryotic translation initiation factor 1A Y-linked) is a protein-coding gene located on chromosome Y.
EIF1AY is a protein encoded by the EIF1AY gene in humans. It is a Y-chromosomal isoform of eukaryotic translation initiation factor 1A (EIF1A), similar to its X-chromosomal counterpart, EIF1AX.
EIF1AY is a key component of the 43S pre-initiation complex (43S PIC), which is responsible for initiating protein synthesis. It plays a crucial role in the process of scanning mRNA, identifying the start codon, and assembling the 48S complex. This protein also helps to orient the initiator tRNA, facilitating the joining of the 60S ribosomal subunit to form the 80S initiation complex. Importantly, EIF1AY interacts with other initiation factors, including EIF5 and EIF5B, to regulate the assembly and disassembly of these complexes. Interestingly, while EIF1AY interacts with EIF5, it does not bind to EIF1, unlike its yeast counterparts.
EIF1AY is also known as eIF-4C.
