EFNA3
Description
The EFNA3 (ephrin A3) is a protein-coding gene located on chromosome 1.
Ephrin A3 is a protein encoded by the EFNA3 gene in humans. It belongs to the ephrin (EPH) family, which comprises the largest subfamily of receptor protein-tyrosine kinases and is involved in developmental processes, particularly in the nervous system and erythropoiesis. Ephrins are categorized into two classes: ephrin-A (EFNA) and ephrin-B (EFNB). EFNA class ephrins, like Ephrin A3, are anchored to the membrane by a glycosylphosphatidylinositol linkage, while EFNB class ephrins are transmembrane proteins.
Ephrin-A3 is a cell surface GPI-anchored ligand that interacts with Eph receptors, a family of receptor tyrosine kinases crucial for cell migration, repulsion, and adhesion during neuronal, vascular, and epithelial development. It binds promiscuously to Eph receptors on adjacent cells, initiating contact-dependent bidirectional signaling. This signaling involves both forward signaling downstream of the Eph receptor and reverse signaling downstream of the ephrin ligand.
EFNA3 is also known as EFL2, EPLG3, Ehk1-L, LERK3.
Associated Diseases
- cataract
- breast cancer
- nail-patella syndrome
- cancer
- COVID-19
- Dravet syndrome
- liver and intrahepatic bile duct neoplasm
