ECSCR
Description
The ECSCR (endothelial cell surface expressed chemotaxis and apoptosis regulator) is a protein-coding gene located on chromosome 5.
ECSCR plays a crucial role in regulating the movement and formation of blood vessel lining cells (endothelial cells). It contributes to the growth of new blood vessels (angiogenesis) and cell death (apoptosis) by influencing the structure of the cell's skeleton (actin cytoskeleton). ECSCR also helps break down proteins that block cell death (BIRC3/IAP1 and BIRC2/IAP2), further regulating apoptosis.
ECSCR is also known as ARIA, ECSM2.
Associated Diseases
- hypertriglyceridemia 2
- cholesterol-ester transfer protein deficiency
- hyperlipidemia due to hepatic triglyceride lipase deficiency
- hypoalphalipoproteinemia, primary, 1
- homozygous familial hypercholesterolemia
- glycogen storage disease III
- glycogen storage disease VI
- caudal duplication
- multicystic dysplastic kidney
- familial apolipoprotein C-II deficiency
