E2F8
E2F8: A Key Regulator in Cell Proliferation and Cancer
Description:
E2F8, short for E2F transcription factor 8, is a protein that plays a pivotal role in regulating cell proliferation and apoptosis (programmed cell death). It belongs to the E2F family of transcription factors, which are essential for controlling the cell cycle.
E2F8 specifically binds to DNA sequences known as E2F binding sites and activates the transcription of genes involved in DNA replication, cell cycle progression, and apoptosis. Its precise regulation is crucial for maintaining normal cell growth and preventing uncontrolled cell division.
Associated Diseases:
Dysregulation of E2F8 has been implicated in various diseases, including:
- Cancer: E2F8 overexpression can promote uncontrolled cell division and inhibit apoptosis, leading to the development of cancer. It has been linked to several types of cancers, including breast cancer, lung cancer, and leukemia.
- Neurological disorders: E2F8 mutations have been associated with neurodevelopmental disorders such as autism spectrum disorder and intellectual disability.
- Cardiovascular diseases: E2F8 has been implicated in the development and progression of cardiovascular diseases, including atherosclerosis and heart failure.
- Immune system dysregulation: E2F8 plays a role in regulating immune responses and its dysfunction can contribute to autoimmune diseases and immunodeficiencies.
Did you Know ?
According to a study published in the journal "Oncogene," E2F8 overexpression was found in over 60% of breast cancer patients. This highlights the significant role of E2F8 in cancer development and its potential as a therapeutic target.
