E2F6
e2f6: A Master Regulator of Cell Cycle and Cancer
Description:
e2f6 is a transcription factor that plays a pivotal role in regulating the cell cycle, the orchestrated sequence of events that ensures the proper growth and division of cells. It belongs to the E2F family of proteins, which are essential for cell cycle progression. e2f6 is particularly critical during the G1/S transition, the point at which cells commit to DNA replication and cell division. It activates the expression of genes involved in DNA synthesis, cell cycle progression, and the inhibition of apoptosis (programmed cell death).
Associated Diseases:
Dysregulation of e2f6 has been linked to a variety of diseases, including:
- Cancer: Overexpression or mutations in e2f6 are found in various types of cancer, including breast cancer, lung cancer, and leukemia. In cancer cells, e2f6 can promote uncontrolled cell growth and proliferation.
- Neurological disorders: Mutations in e2f6 have been identified in patients with neurodevelopmental disorders, such as autism spectrum disorder and intellectual disability.
- Immune disorders: e2f6 is involved in the regulation of immune cell function, and its dysregulation can contribute to autoimmune diseases.
Did you Know ?
Research has shown that overexpression of e2f6 occurs in approximately 20-30% of human cancers, highlighting its significant role in tumorigenesis.
