E2F4
e2f4: The Mysterious Transcription Factor
Description
E2f4 is a transcription factor that plays a crucial role in cell growth, proliferation, differentiation, and apoptosis. It belongs to the E2F family of transcription factors, which are known for regulating cell cycle progression and cellular processes.
E2f4 is composed of two subunits, E2F4a and E2F4b, which are encoded by separate genes. It interacts with other transcription factors, such as Rb, p53, and Myc, to regulate gene expression and influence cell fate decisions.
Associated Diseases
Dysregulation of E2f4 has been implicated in several human diseases, including:
- Cancer: E2f4 overexpression is often observed in various types of cancer, including lung cancer, breast cancer, and retinoblastoma.
- Neurological disorders: E2f4 has been linked to neurodegenerative diseases such as Alzheimer‘s disease and Parkinson‘s disease.
- Developmental disorders: Mutations in E2f4 have been associated with developmental disorders such as Rubinstein-Taybi syndrome and Kabuki syndrome.
Did you Know ?
A study published in the journal Nature Medicine found that women with high levels of E2f4 expression in their breast tumors had a significantly higher risk of developing metastatic breast cancer.
