E2F3
E2F3: The Transcription Factor Controlling Cell Growth and Death
Description:
E2F3 is a transcription factor that plays a crucial role in regulating cell growth, proliferation, and apoptosis (programmed cell death). It belongs to the E2F family of transcription factors, which are key regulators of the cell cycle. E2F3 is specifically involved in the transition from the G1 to S phase of the cell cycle, which is the point at which cells commit to DNA replication and cell division.
Associated Diseases:
Dysregulation of E2F3 has been implicated in several human diseases, including:
- Cancer: Aberrant E2F3 expression is associated with various types of cancer, such as breast cancer, lung cancer, and leukemia.
- Neurodegenerative diseases: Impairments in E2F3 function have been linked to neurodegenerative diseases such as Alzheimer‘s disease and Parkinson‘s disease.
- Autoimmune disorders: Dysregulated E2F3 activity has been implicated in the development of autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.
Did you Know ?
Studies have shown that elevated E2F3 expression is found in approximately 50% of breast cancer cases. This suggests that E2F3 dysregulation may play a significant role in the development of breast cancer.
