E2F2
Title: E2F2: The Gene that Regulates Cell Growth and Division
Description:
E2F2 is a transcription factor gene that plays a crucial role in regulating cell cycle progression, particularly during the transition from the G1 to S phase. This gene encodes a protein that binds to specific DNA sequences and controls the expression of genes involved in DNA replication, cell cycle progression, and apoptosis. Dysregulation of E2F2 can lead to abnormal cell growth and proliferation, contributing to the development of various diseases.
Associated Diseases:
Alterations in E2F2 have been linked to several human diseases, including:
- Cancer: E2F2 deregulation is commonly observed in different types of cancer, including breast, lung, colon, and prostate cancer. Overexpression of E2F2 can promote uncontrolled cell growth and proliferation, while its loss or mutations can disrupt cell cycle regulation and lead to tumor development.
- Neurodegenerative disorders: E2F2 deficiency has been implicated in neurodegenerative diseases such as Alzheimer‘s disease and Parkinson‘s disease. It is believed that E2F2 plays a role in neuronal survival and differentiation, and its dysfunction can contribute to neuronal degeneration.
- Developmental abnormalities: Mutations in E2F2 can cause developmental abnormalities, including skeletal deformities, growth retardation, and mental disabilities. These effects highlight the essential role of E2F2 in regulating embryonic development.
Did you Know ?
Approximately 30% of human cancers harbor alterations in E2F2 or its regulatory pathway, highlighting the significance of this gene in cancer development.
