DYNLT3
Description
The DYNLT3 (dynein light chain Tctex-type 3) is a protein-coding gene located on chromosome X.
DYNLT3, also known as Dynein, light chain, Tctex-type 3, is a protein encoded by the DYNLT3 gene. It is part of the dynein motor protein family. DYNLT3 binds to BUB3, a spindle checkpoint protein involved in cell division, and can also act as a transcription regulator for the Bcl-2 gene by interacting with SATB1. It has been shown to interact with VDAC1.
DYNLT3 is a non-catalytic component of the cytoplasmic dynein 1 complex, which is responsible for the movement of vesicles and organelles along microtubules within cells. It likely plays a role in attaching dynein to cargo and interacting with adapter proteins that control dynein's function. DYNLT3 is also thought to bind to BUB3, a protein involved in cell division, as part of the cargo being transported. Its presence is important for the efficient completion of mitosis.
DYNLT3 is also known as RP3, TCTE1L, TCTEX1L.
Associated Diseases
- cancer
- breast cancer
- Parkinson disease
- salivary gland adenoid cystic carcinoma
- serous cystadenocarcinoma
