DUSP8
Description
The DUSP8 (dual specificity phosphatase 8) is a protein-coding gene located on chromosome 11.
DUSP8 is a human gene encoding a protein belonging to the dual specificity protein phosphatase subfamily. These phosphatases inactivate target kinases by dephosphorylating both phosphoserine/threonine and phosphotyrosine residues, negatively regulating members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38) involved in cellular proliferation and differentiation. DUSP8 specifically inactivates SAPK/JNK and p38, is predominantly expressed in the adult brain, heart, and skeletal muscle, localizes in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is found on chromosome 10q11.2.
DUSP8 exhibits phosphatase activity with synthetic substrates and plays a regulatory role in suppressing mitogen-activated protein kinase (MAPK) activity. It is believed to achieve this regulation by catalyzing the dephosphorylation of MAPKs. DUSP8 is expected to display protein phosphatase activity towards phosphotyrosine, phosphoserine, and phosphothreonine residues.
DUSP8 is also known as C11orf81, HB5, HVH-5, HVH8.
Associated Diseases
- thyroid gland adenocarcinoma
- endometrial cancer
- left ventricular noncompaction
- left ventricular noncompaction 10
- dilated cardiomyopathy 1AA
- dilated cardiomyopathy 1GG
- autosomal recessive limb-girdle muscular dystrophy type 2L
- sick sinus syndrome 2, autosomal dominant
- congenital heart block
