DRG2
Description
The DRG2 (developmentally regulated GTP binding protein 2) is a protein-coding gene located on chromosome 17.
DRG2 is a protein encoded by the DRG2 gene in humans. Its name comes from its similarity to known GTP-binding proteins and its expression in normal fibroblasts but not in SV40-transformed fibroblasts. Read-through transcripts involving DRG2 and a downstream gene have been identified but are not thought to encode a fusion protein. The DRG2 gene is located within the Smith-Magenis syndrome region on chromosome 17.
DRG2 catalyzes the conversion of GTP to GDP by hydrolyzing the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, DRG2 can bind to RNA and potentially play a role in translation.
DRG2 is also known as -.
Associated Diseases
- schizophrenia
- bipolar disorder
- anorexia nervosa
- syndactyly type 4
- tibia, hypoplasia or aplasia of, with polydactyly
- spondyloepimetaphyseal dysplasia, Missouri type
- acromesomelic dysplasia 2C, Hunter-Thompson type
