DRD3
Description
The DRD3 (dopamine receptor D3) is a protein-coding gene located on chromosome 3.
The DRD3 gene encodes the D3 subtype of the dopamine receptor, which inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is expressed in older brain regions, suggesting a role in cognitive and emotional functions. It is a target for drugs treating schizophrenia, drug addiction, and Parkinson's disease. Alternative splicing produces multiple transcript variants, some potentially subject to nonsense-mediated decay (NMD). D3 agonists like 7-OH-DPAT, pramipexole, and rotigotine exhibit antidepressant effects in rodent models of depression. Apomorphine may aid PD patients with cognitive awareness. D3 agonists reduce α-synuclein aggregation, a hallmark of Parkinson's disease, by increasing dopamine levels through inhibiting reuptake and breakdown. This regulation enhances BDNF secretion, mitigating neuroinflammation and oxidative stress while promoting neurogenesis and interacting with other dopamine receptors.
DRD3 is also known as D3DR, ETM1, FET1.
