DRD2
Description
The DRD2 (dopamine receptor D2) is a protein-coding gene located on chromosome 11.
The dopamine D2 receptor (D2R), encoded by the DRD2 gene, is a key receptor for many antipsychotic drugs. It is a G protein-coupled receptor that inhibits adenylyl cyclase activity when coupled to the Gi subtype of G protein. The D2R plays a role in various brain functions, including memory formation, fear memory retrieval, and discrimination learning. In mice, the neuronal calcium sensor-1 (NCS-1) regulates D2R surface expression in the dentate gyrus, impacting exploration and synaptic plasticity. The activation of the D2 autoreceptor in flies protects dopamine neurons from cell death induced by MPP+, a toxin mimicking Parkinson's disease pathology. While optimal dopamine levels favor D1R cognitive stabilization, the D2R mediates cognitive flexibility in humans.
The D2 dopamine receptor, also known as Dopamine D2 receptor, is a G protein-coupled receptor whose activity is mediated by G proteins, which inhibit adenylyl cyclase. This receptor plays a role in the postnatal regression of retinal hyaloid vessels by suppressing the activity of VEGFR2/KDR downstream of OPN5.
DRD2 is also known as D2DR, D2R.
