DPF3
Description
The DPF3 (double PHD fingers 3) is a protein-coding gene located on chromosome 14.
DPF3, also known as BRG1-associated factor 45C or Zinc finger protein cer-d4, is a protein that in humans is encoded by the DPF3 gene. It belongs to the neuron-specific chromatin remodeling complex (nBAF complex). DPF3 plays a critical role in neural development by switching from a stem/progenitor to a post-mitotic chromatin remodeling mechanism as neurons exit the cell cycle and commit to their adult state. It is also a muscle-specific component of the BAF complex, involved in transcriptional activation and repression of select genes by chromatin remodeling. DPF3 specifically binds acetylated lysines on histone 3 and 4, acting as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. This protein is essential for heart and skeletal muscle development.
DPF3, also known as BAF45C, is a component of the neuron-specific chromatin remodeling complex (nBAF). It plays a crucial role in neural development by facilitating the transition from proliferating neural stem/progenitor cells to post-mitotic neurons. During this transition, DPF3 replaces PHF10/BAF45A in the nBAF complex, contributing to the regulation of genes essential for dendrite growth. In muscle cells, DPF3 acts as a muscle-specific component of the BAF complex, influencing transcriptional activation and repression through chromatin remodeling. It binds to acetylated lysines on histone 3 and 4, serving as an anchor between histone modifications and chromatin remodeling. This function is essential for heart and skeletal muscle development.
DPF3 is also known as BAF45C, CERD4, SMARCG3.
