DPF1
Description
The DPF1 (double PHD fingers 1) is a protein-coding gene located on chromosome 19.
DPF1, zinc and double PHD fingers family 1 is a protein that in humans is encoded by the DPF1 gene.
DPF1 is a crucial component of the neuron-specific chromatin remodeling complex (nBAF), which plays a vital role in regulating gene expression during neuronal development. The nBAF complex is involved in the transition from proliferating neural stem cells to postmitotic neurons. DPF1, along with other nBAF subunits, contributes to the switch in subunit composition of the complex, enabling it to regulate genes essential for dendrite growth. DPF1's presence within nBAF may be critical for the self-renewal and proliferation of neural stem cells. It is also suggested that DPF1 might act as a neurospecific transcription factor, influencing cell survival during neuronal development.
DPF1 is also known as BAF45b, NEUD4, SMARCG1, neuro-d4.
Associated Diseases
- schizophrenia 15
- Phelan-McDermid syndrome
- Zika virus infectious disease
- cancer
- neuroendocrine carcinoma
- glioblastoma
