DPCR1
Title: dpcr1: A Critical Gene with Wide-Ranging Implications
Description:
dpcr1 (Deleted in Polyposis Colorectal Cancer 1) is a crucial gene involved in the regulation of cell division, apoptosis, and DNA repair. Mutations or dysregulation of dpcr1 have been implicated in various diseases, including colorectal cancer, lung cancer, and leukemia.
Associated Diseases:
- Colorectal Cancer: Mutations in dpcr1 are commonly found in patients with colorectal cancer, particularly those with Lynch syndrome. These mutations can lead to uncontrolled cell growth and the development of cancerous tumors.
- Lung Cancer: Alterations in dpcr1 expression have been associated with the development of lung cancer. Studies have shown that reduced dpcr1 levels can promote tumor growth and metastasis.
- Leukemia: Dysregulation of dpcr1 has been implicated in the pathogenesis of leukemia, particularly in acute myeloid leukemia (AML). Mutations in dpcr1 can disrupt normal cell cycle regulation and contribute to the development of the disease.
Did you Know ?
According to a study published in the journal "Nature Genetics," individuals with a mutation in dpcr1 have a 20-fold increased risk of developing colorectal cancer compared to the general population.
