DNAJC8
Description
The DNAJC8 (DnaJ heat shock protein family (Hsp40) member C8) is a protein-coding gene located on chromosome 1.
DNAJC8 has been shown to suppress the aggregation of polyglutamine (polyQ) stretches within the ATXN3 protein, which is linked to the neurodegenerative disease spinocerebellar ataxia type 3 (SCA3). This suggests DNAJC8 may play a role in protecting neuronal cells from protein misfolding and aggregation.
DNAJC8 is also known as HSPC331, SPF31.
Associated Diseases
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- alpha thalassemia-intellectual disability syndrome type 1
- delta-beta-thalassemia
- hemoglobin D disease
- hemoglobin E-beta-thalassemia syndrome
- hemolytic anemia due to adenylate kinase deficiency
- hemoglobin C-beta-thalassemia syndrome
- alpha-thalassemia-myelodysplastic syndrome
- Heinz body anemia
