DLX1
Description
The DLX1 (distal-less homeobox 1) is a protein-coding gene located on chromosome 2.
DLX1 is a gene that encodes a protein called DLX-1, a member of a homeobox transcription factor gene family resembling the Drosophila distal-less gene. The protein resides in the nucleus, where it functions as a regulator of gene expression, influenced by various members of the TGF-β superfamily. It's believed to play a role in shaping the craniofacial features and in the differentiation and survival of specific neurons in the forebrain. This gene is situated close to another member of the same family on chromosome 2. Alternative splicing of this gene produces multiple forms of the DLX-1 protein.
DLX1 is also known as -.
Associated Diseases
- progressive deafness with stapes fixation
- deafness-ear malformation-facial palsy syndrome
- thickened earlobes-conductive deafness syndrome
- cancer
- cleft lip/palate
- middle ear neuroendocrine tumor
- branchiootic syndrome
