DLGAP1
Description
The DLGAP1 (DLG associated protein 1) is a protein-coding gene located on chromosome 18.
Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a protein that in humans is encoded by the DLGAP1 gene. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the post-synaptic density.
== Function == This gene encodes the protein called guanylate kinase-associated protein (GKAP). GKAP binds to the SHANK2 and PSD-95 proteins, facilitating the assembly of the post-synaptic density of neurons. Dlgap1 has five 14-amino-acid repeats and three Pro-rich portions.
== Interactions == DLGAP1 has been shown to interact with:
DLG1 DLG4 DYNLL1 DYNLL2 SHANK2 The interaction with PSD95 and S-SCAM is mediated by the GUK domain and it has been hypothesized that this might mean it can also interact with other GUK containing proteins.
Plays a crucial role in the postsynaptic scaffold of neuronal cells, contributing to the structural and functional organization of synapses.
DLGAP1 is also known as DAP-1, DAP-1-ALPHA, DAP-1-BETA, DAP1, DLGAP1A, DLGAP1B, GKAP, SAPAP1.